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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:mitogen activated protein kinase signaling pathway
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Accession:PW:0000007 term browser browse the term
Definition:The mitogen-activated protein kinase pathway groups several serine/threonine protein kinase mediated cascades in response to a number of extracellular stimuli. A characteristic feature of these cascades is the presence of at least three kinases in series leading to the activation of a multifunctional MAP kinase.
Synonyms:related_synonym: MAPK cascade;   MAPK family signaling cascades;   MAPK signaling pathway
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mitogen activated protein kinase signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO RGD PMID:16168116 RGD:1582137 NCBI chrNW_004624795:3,373,313...3,391,509
Ensembl chrNW_004624795:3,373,000...3,391,602 		JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 ISO RGD PMID:9779826 RGD:70317 NCBI chrNW_004624863:442,465...609,159
Ensembl chrNW_004624863:439,541...525,918 		JBrowse link
G Shc1 SHC adaptor protein 1 ISO RGD PMID:12837289 RGD:1304398 NCBI chrNW_004624885:2,511,039...2,520,883
Ensembl chrNW_004624885:2,511,240...2,521,155 		JBrowse link
G Tsc2 TSC complex subunit 2 ISO RGD PMID:14612383 RGD:1580517 NCBI chrNW_004624913:166,931...203,008
Ensembl chrNW_004624913:166,931...202,953 		JBrowse link
altered Erk5 MAPK signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Map2k5 mitogen-activated protein kinase kinase 5 ISO RGD PMID:16376520 RGD:2298532 NCBI chrNW_004624781:5,224,722...5,489,517
Ensembl chrNW_004624781:5,224,724...5,489,488 		JBrowse link
G Mapk7 mitogen-activated protein kinase 7 ISO RGD PMID:16376520 RGD:2298532 NCBI chrNW_004624849:5,655,631...5,661,779
Ensembl chrNW_004624849:5,656,515...5,664,721 		JBrowse link
altered extracellular signal-regulated Raf/Mek/Erk signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO RGD PMID:17126425 PMID:18098337 PMID:20951313 PMID:21277552 RGD:2293882 RGD:2298531 RGD:5133242 RGD:5133243 NCBI chrNW_004624765:20,766,368...20,951,560
Ensembl chrNW_004624765:20,773,885...20,951,736 		JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO RGD PMID:16112461 PMID:18772397 PMID:19078924 PMID:19506583 PMID:20951313 RGD:2306732 RGD:4143515 RGD:5133242 RGD:5490965 RGD:5490966 NCBI chrNW_004624752:13,809,741...13,847,020
Ensembl chrNW_004624752:13,809,775...13,844,166 		JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 ISO RGD PMID:20951313 PMID:21277552 RGD:5133242 RGD:5133243 NCBI chrNW_004624781:6,222,365...6,285,398
Ensembl chrNW_004624781:6,222,365...6,285,531 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO RGD PMID:17126425 RGD:2293882 NCBI chrNW_004624872:204,357...284,487
Ensembl chrNW_004624872:204,357...269,135 		JBrowse link
c-Jun N-terminal kinases MAPK signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc42 cell division cycle 42 ISO RGD PMID:8910292 PMID:9305638 RGD:2293876 RGD:2293879 NCBI chrNW_004624764:6,874,453...6,891,952 JBrowse link
G Dusp10 dual specificity phosphatase 10 ISO RGD PMID:17208316 RGD:2293881 NCBI chrNW_004624835:4,751,651...4,783,916
Ensembl chrNW_004624835:4,750,077...4,782,249 		JBrowse link
G Dusp16 dual specificity phosphatase 16 ISO RGD PMID:17208316 RGD:2293881 NCBI chrNW_004624752:25,340,997...25,413,561
Ensembl chrNW_004624752:25,340,448...25,413,561 		JBrowse link
G Dusp19 dual specificity phosphatase 19 ISO RGD PMID:11959862 RGD:2314491 NCBI chrNW_004624844:4,798,542...4,822,739
Ensembl chrNW_004624844:4,798,455...4,818,818 		JBrowse link
G Dusp8 dual specificity phosphatase 8 ISO RGD PMID:17208316 RGD:2293881 NCBI chrNW_004624766:21,203,180...21,215,919
Ensembl chrNW_004624766:21,205,991...21,216,222 		JBrowse link
G Map2k4 mitogen-activated protein kinase kinase 4 ISO RGD PMID:10051439 PMID:17064355 PMID:17306896 RGD:2293875 RGD:2298561 RGD:2298577 NCBI chrNW_004624786:14,457,382...14,597,027
Ensembl chrNW_004624786:14,457,452...14,597,027 		JBrowse link
G Map2k7 mitogen-activated protein kinase kinase 7 ISO RGD PMID:10051439 PMID:15680699 PMID:17064355 PMID:17306896 RGD:2293875 RGD:2298561 RGD:2298567 RGD:2298577 NCBI chrNW_004624828:869,424...878,358
Ensembl chrNW_004624828:869,425...878,231 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 ISO RGD PMID:9305638 PMID:17306896 RGD:2293875 RGD:2293879 NCBI chrNW_004624759:2,360,655...2,429,189
Ensembl chrNW_004624759:2,363,076...2,428,273 		JBrowse link
G Map3k10 mitogen-activated protein kinase kinase kinase 10 ISO RGD PMID:17306896 RGD:2293875 NCBI chrNW_004624925:232,397...250,083
Ensembl chrNW_004624925:232,986...249,794 		JBrowse link
G Map3k11 mitogen-activated protein kinase kinase kinase 11 ISO RGD PMID:8910292 PMID:15680699 PMID:17064355 PMID:17306896 RGD:2293875 RGD:2293876 RGD:2298567 RGD:2298577 NCBI chrNW_004624767:20,780,356...20,796,015
Ensembl chrNW_004624767:20,779,898...20,796,015 		JBrowse link
G Map3k12 mitogen-activated protein kinase kinase kinase 12 ISO RGD PMID:17306896 RGD:2293875 NCBI chrNW_004624904:1,579,792...1,598,595
Ensembl chrNW_004624904:1,578,986...1,598,939 		JBrowse link
G Map3k13 mitogen-activated protein kinase kinase kinase 13 ISO RGD PMID:17306896 RGD:2293875 NCBI chrNW_004624730:71,162,598...71,313,369
Ensembl chrNW_004624730:71,161,646...71,312,442 		JBrowse link
G Map3k2 mitogen-activated protein kinase kinase kinase 2 ISO RGD PMID:9305638 PMID:17306896 RGD:2293875 RGD:2293879 NCBI chrNW_004624732:13,790,088...13,877,641
Ensembl chrNW_004624732:13,790,080...13,877,598 		JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 ISO RGD PMID:17306896 RGD:2293875 NCBI chrNW_004624787:10,392,738...10,566,563
Ensembl chrNW_004624787:10,405,701...10,565,943 		JBrowse link
G Map3k21 mitogen-activated protein kinase kinase kinase 21 ISO RGD PMID:17306896 RGD:2293875 NCBI chrNW_004624775:16,707,932...16,759,175
Ensembl chrNW_004624775:16,706,715...16,759,208 		JBrowse link
G Map3k3 mitogen-activated protein kinase kinase kinase 3 ISO RGD PMID:9305638 PMID:17306896 RGD:2293875 RGD:2293879 NCBI chrNW_004624849:1,118,275...1,186,244
Ensembl chrNW_004624849:1,118,492...1,185,777 		JBrowse link
G Map3k4 mitogen-activated protein kinase kinase kinase 4 ISO RGD PMID:9305638 PMID:17306896 RGD:2293875 RGD:2293879 NCBI chrNW_004624855:2,174,141...2,298,219
Ensembl chrNW_004624855:2,174,097...2,298,259 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 ISO RGD PMID:12215209 PMID:17306896 RGD:2293875 RGD:2296020 NCBI chrNW_004624886:970,415...1,189,595
Ensembl chrNW_004624886:969,623...1,190,709 		JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 ISO RGD PMID:17306896 RGD:2293875 NCBI chrNW_004624799:3,554,644...3,623,317
Ensembl chrNW_004624799:3,554,678...3,622,289 		JBrowse link
G Map3k9 mitogen-activated protein kinase kinase kinase 9 ISO RGD PMID:17306896 RGD:2293875 NCBI chrNW_004624734:30,412,019...30,484,292
Ensembl chrNW_004624734:30,412,008...30,477,507 		JBrowse link
G Mapk10 mitogen-activated protein kinase 10 ISO RGD PMID:10051439 PMID:15680699 PMID:17306896 RGD:2293875 RGD:2298561 RGD:2298567 NCBI chrNW_004624872:2,460,308...2,830,569
Ensembl chrNW_004624872:2,461,362...2,825,161 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO RGD PMID:10051439 PMID:17064355 PMID:17306896 RGD:2293875 RGD:2298561 RGD:2298577 NCBI chrNW_004624928:1,442,216...1,494,275
Ensembl chrNW_004624928:1,439,146...1,494,266 		JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 ISO RGD PMID:15816852 PMID:17726577 RGD:1579811 RGD:2293880 NCBI chrNW_004624767:2,603,483...2,620,574
Ensembl chrNW_004624767:2,603,483...2,620,536 		JBrowse link
G Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 ISO RGD PMID:17726577 RGD:2293880 NCBI chrNW_004624752:162,724...171,984
Ensembl chrNW_004624752:163,462...171,859 		JBrowse link
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 ISO RGD PMID:17726577 RGD:2293880 NCBI chrNW_004624913:481,236...529,083
Ensembl chrNW_004624913:481,207...529,070 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 ISO RGD PMID:10051439 PMID:17064355 PMID:17306896 RGD:2293875 RGD:2298561 RGD:2298577 NCBI chrNW_004624733:42,998,948...43,048,392
Ensembl chrNW_004624733:42,999,339...43,048,285 		JBrowse link
G Rac1 Rac family small GTPase 1 ISO RGD PMID:8910292 PMID:9305638 RGD:2293876 RGD:2293879 NCBI chrNW_004624740:30,912,841...30,933,882
Ensembl chrNW_004624740:30,911,598...30,934,025 		JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 ISO RGD PMID:10811109 RGD:11534984 NCBI chrNW_004624760:4,376,733...4,474,834
Ensembl chrNW_004624760:4,376,713...4,474,837 		JBrowse link
G Spp1 secreted phosphoprotein 1 ISO RGD PMID:15757900 RGD:1581337 NCBI chrNW_004624872:4,505,796...4,513,247
Ensembl chrNW_004624872:4,505,522...4,513,742 		JBrowse link
G Traf2 TNF receptor associated factor 2 ISO RGD PMID:12215209 RGD:2296020 NCBI chrNW_004624760:952,574...973,511
Ensembl chrNW_004624760:952,574...965,661 		JBrowse link
Erk5 MAPK signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Map2k5 mitogen-activated protein kinase kinase 5 ISO RGD PMID:15631999 PMID:16376520 RGD:1582263 RGD:2298532 NCBI chrNW_004624781:5,224,722...5,489,517
Ensembl chrNW_004624781:5,224,724...5,489,488 		JBrowse link
G Map3k2 mitogen-activated protein kinase kinase kinase 2 ISO RGD PMID:16376520 RGD:2298532 NCBI chrNW_004624732:13,790,088...13,877,641
Ensembl chrNW_004624732:13,790,080...13,877,598 		JBrowse link
G Map3k3 mitogen-activated protein kinase kinase kinase 3 ISO RGD PMID:16376520 RGD:2298532 NCBI chrNW_004624849:1,118,275...1,186,244
Ensembl chrNW_004624849:1,118,492...1,185,777 		JBrowse link
G Mapk7 mitogen-activated protein kinase 7 ISO RGD PMID:11782488 PMID:16376520 RGD:2298532 RGD:2298794 NCBI chrNW_004624849:5,655,631...5,661,779
Ensembl chrNW_004624849:5,656,515...5,664,721 		JBrowse link
G Sh2d2a SH2 domain containing 2A ISO RGD PMID:16376520 RGD:2298532 NCBI chrNW_004624885:1,951,442...1,960,292
Ensembl chrNW_004624885:1,952,387...1,960,424 		JBrowse link
G Wnk1 WNK lysine deficient protein kinase 1 ISO RGD PMID:16376520 RGD:2298532 NCBI chrNW_004624735:8,987,390...9,122,277
Ensembl chrNW_004624735:8,987,469...9,124,516 		JBrowse link
p38 MAPK signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin ISO RGD PMID:16157033 RGD:1625329 NCBI chrNW_004624766:2,402,152...2,404,343
Ensembl chrNW_004624766:2,401,769...2,404,446 		JBrowse link
G Atm ATM serine/threonine kinase ISO PID PID:200018 NCBI chrNW_004624784:2,933,172...3,080,131
Ensembl chrNW_004624784:2,937,499...3,078,216 		JBrowse link
G Bnip2 BCL2 interacting protein 2 ISO RGD PMID:20626350 RGD:7240533 NCBI chrNW_004624781:12,468,675...12,497,130
Ensembl chrNW_004624781:12,468,711...12,488,360 		JBrowse link
G Calm1 calmodulin 1 ISO PID PID:200018 NCBI chrNW_004624734:12,030,264...12,041,682
Ensembl chrNW_004624734:12,030,001...12,041,772 		JBrowse link
G Calm2 calmodulin 2 ISO PID PID:200018 NCBI chrNW_004624738:28,525,290...28,541,562
Ensembl chrNW_004624738:28,525,285...28,541,514 		JBrowse link
G Calm3 calmodulin 3 ISO PID PID:200018 NCBI chrNW_004624832:6,957,775...6,966,505
Ensembl chrNW_004624832:6,958,820...6,966,514 		JBrowse link
G Camk2b calcium/calmodulin dependent protein kinase II beta ISO PID PID:200018 NCBI chrNW_004624740:7,750,327...7,828,891
Ensembl chrNW_004624740:7,750,245...7,831,454 		JBrowse link
G Ccm2 CCM2 scaffold protein ISO RGD
PID		 PMID:17481747 PMID:20626350 PID:200018 RGD:2293891 RGD:7240533 NCBI chrNW_004624740:7,308,178...7,348,681
Ensembl chrNW_004624740:7,308,177...7,348,689 		JBrowse link
G Cdc42 cell division cycle 42 ISO RGD PMID:20626350 RGD:7240533 NCBI chrNW_004624764:6,874,453...6,891,952 JBrowse link
G Cdon cell adhesion associated, oncogene regulated ISO RGD PMID:20626350 RGD:7240533 NCBI chrNW_004624812:107,632...203,791
Ensembl chrNW_004624812:109,405...203,519 		JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 ISO RGD PMID:20626350 RGD:7240533 NCBI chrNW_004624734:3,363,084...3,372,790
Ensembl chrNW_004624734:3,363,001...3,372,694 		JBrowse link
G Dusp10 dual specificity phosphatase 10 ISO RGD PMID:20626350 RGD:7240533 NCBI chrNW_004624835:4,751,651...4,783,916
Ensembl chrNW_004624835:4,750,077...4,782,249 		JBrowse link
G Dusp16 dual specificity phosphatase 16 ISO RGD PMID:20626350 RGD:7240533 NCBI chrNW_004624752:25,340,997...25,413,561
Ensembl chrNW_004624752:25,340,448...25,413,561 		JBrowse link
G Dusp9 dual specificity phosphatase 9 ISO RGD PMID:20626350 RGD:7240533 NCBI chrNW_004624946:359,273...366,310
Ensembl chrNW_004624946:359,377...366,308 		JBrowse link
G Gadd45a growth arrest and DNA damage inducible alpha ISO PID PID:200018 NCBI chrNW_004624742:27,727,801...27,730,252
Ensembl chrNW_004624742:27,727,660...27,730,316 		JBrowse link
G Gadd45b growth arrest and DNA damage inducible beta ISO PID PID:200018 NCBI chrNW_004624828:5,663,604...5,665,666
Ensembl chrNW_004624828:5,663,485...5,665,666 		JBrowse link
G Gadd45g growth arrest and DNA damage inducible gamma ISO PID PID:200018 NCBI chrNW_004624765:22,959,751...22,961,371
Ensembl chrNW_004624765:22,959,373...22,961,491 		JBrowse link
G Irf1 interferon regulatory factor 1 ISO RGD PMID:15141302 RGD:5128786 NCBI chrNW_004624733:39,596,565...39,603,428
Ensembl chrNW_004624733:39,596,501...39,603,526 		JBrowse link
G Map2k3 mitogen-activated protein kinase kinase 3 ISO RGD
PID		 PMID:16183734 PMID:17481747 PID:200018 RGD:2293891 RGD:2298758 NCBI chrNW_004624849:5,007,185...5,034,488
Ensembl chrNW_004624849:5,006,513...5,035,747 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 ISO PID
RGD		 PMID:16183734 PMID:17481747 PID:200018 RGD:2293891 RGD:2298758 NCBI chrNW_004624870:4,224,108...4,420,217
Ensembl chrNW_004624870:4,287,835...4,416,559 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 ISO PID PID:200018 NCBI chrNW_004624759:2,360,655...2,429,189
Ensembl chrNW_004624759:2,363,076...2,428,273 		JBrowse link
G Map3k10 mitogen-activated protein kinase kinase kinase 10 ISO PID PID:200018 NCBI chrNW_004624925:232,397...250,083
Ensembl chrNW_004624925:232,986...249,794 		JBrowse link
G Map3k11 mitogen-activated protein kinase kinase kinase 11 ISO RGD PMID:20626350 RGD:7240533 NCBI chrNW_004624767:20,780,356...20,796,015
Ensembl chrNW_004624767:20,779,898...20,796,015 		JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 ISO RGD PMID:20626350 RGD:7240533 NCBI chrNW_004624787:10,392,738...10,566,563
Ensembl chrNW_004624787:10,405,701...10,565,943 		JBrowse link
G Map3k3 mitogen-activated protein kinase kinase kinase 3 ISO PID
RGD		 PMID:17481747 PMID:20626350 PID:200018 RGD:2293891 RGD:7240533 NCBI chrNW_004624849:1,118,275...1,186,244
Ensembl chrNW_004624849:1,118,492...1,185,777 		JBrowse link
G Map3k4 mitogen-activated protein kinase kinase kinase 4 ISO PID
RGD		 PMID:20626350 PID:200018 RGD:7240533 NCBI chrNW_004624855:2,174,141...2,298,219
Ensembl chrNW_004624855:2,174,097...2,298,259 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 ISO RGD
PID		 PMID:12215209 PMID:17481747 PMID:20626350 PID:200018 RGD:2293891 RGD:2296020 RGD:7240533 NCBI chrNW_004624886:970,415...1,189,595
Ensembl chrNW_004624886:969,623...1,190,709 		JBrowse link
G Map3k6 mitogen-activated protein kinase kinase kinase 6 ISO PID PID:200018 NCBI chrNW_004624764:11,250,859...11,263,378
Ensembl chrNW_004624764:11,252,230...11,262,930 		JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 ISO RGD
PID		 PMID:16183734 PMID:17481747 PMID:20626350 PID:200018 RGD:2293891 RGD:2298758 RGD:7240533 NCBI chrNW_004624799:3,554,644...3,623,317
Ensembl chrNW_004624799:3,554,678...3,622,289 		JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 ISO RGD PMID:20626350 RGD:7240533 NCBI chrNW_004624805:2,611,297...2,633,650
Ensembl chrNW_004624805:2,611,038...2,633,943 		JBrowse link
G Mapk11 mitogen-activated protein kinase 11 ISO PID
RGD		 PMID:17481747 PID:200018 RGD:2293891 NCBI chrNW_004624752:502,411...508,452
Ensembl chrNW_004624752:502,350...508,449 		JBrowse link
G Mapk12 mitogen-activated protein kinase 12 ISO RGD PMID:17481747 RGD:2293891 NCBI chrNW_004624752:510,593...518,065
Ensembl chrNW_004624752:510,601...518,065 		JBrowse link
G Mapk13 mitogen-activated protein kinase 13 ISO RGD PMID:17481747 RGD:2293891 NCBI chrNW_004624754:21,506,086...21,513,803
Ensembl chrNW_004624754:21,506,369...21,513,801 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 ISO RGD
PID		 PMID:16407200 PMID:17481747 PID:200018 RGD:1580544 RGD:2293891 NCBI chrNW_004624754:21,528,121...21,598,064
Ensembl chrNW_004624754:21,527,333...21,597,733 		JBrowse link
G Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 ISO RGD PMID:12024021 PMID:17481747 RGD:2293891 RGD:2302280 NCBI chrNW_004624752:162,724...171,984
Ensembl chrNW_004624752:163,462...171,859 		JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 ISO RGD PMID:16421520 RGD:2315047 NCBI chrNW_004624807:4,726,511...4,774,945
Ensembl chrNW_004624807:4,724,234...4,796,143 		JBrowse link
G Mapkapk3 MAPK activated protein kinase 3 ISO RGD PMID:16421520 RGD:2315047 NCBI chrNW_004624730:4,446,815...4,492,753
Ensembl chrNW_004624730:4,446,850...4,476,630 		JBrowse link
G Mapkapk5 MAPK activated protein kinase 5 ISO RGD PMID:16421520 RGD:2315047 NCBI chrNW_004624747:20,344,078...20,384,880
Ensembl chrNW_004624747:20,344,078...20,384,894 		JBrowse link
G Mknk1 MAPK interacting serine/threonine kinase 1 ISO RGD PMID:16421520 RGD:2315047 NCBI chrNW_004624906:2,442,590...2,494,724
Ensembl chrNW_004624906:2,439,418...2,473,967 		JBrowse link
G Mknk2 MAPK interacting serine/threonine kinase 2 ISO RGD PMID:16421520 RGD:2315047 NCBI chrNW_004624828:6,788,069...6,801,370 JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent 1D ISO RGD PMID:20626350 RGD:7240533 NCBI chrNW_004624871:3,044,718...3,089,042
Ensembl chrNW_004624871:3,044,102...3,088,981 		JBrowse link
G Rac1 Rac family small GTPase 1 ISO PID
RGD		 PMID:17481747 PID:200018 RGD:2293891 NCBI chrNW_004624740:30,912,841...30,933,882
Ensembl chrNW_004624740:30,911,598...30,934,025 		JBrowse link
G Rps6ka4 ribosomal protein S6 kinase A4 ISO RGD PMID:16421520 RGD:2315047 NCBI chrNW_004624767:21,958,940...21,970,998
Ensembl chrNW_004624767:21,958,868...21,971,108 		JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 ISO RGD PMID:16421520 RGD:2315047 NCBI chrNW_004624734:11,499,372...11,660,564
Ensembl chrNW_004624734:11,499,637...11,659,536 		JBrowse link
G Spag9 sperm associated antigen 9 ISO RGD PMID:20626350 RGD:7240533 NCBI chrNW_004624795:6,748,513...6,863,201
Ensembl chrNW_004624795:6,745,537...6,863,173 		JBrowse link
G Tab1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 ISO PID PID:200018 NCBI chrNW_004624752:8,912,467...8,937,313
Ensembl chrNW_004624752:8,913,900...8,937,329 		JBrowse link
G Tab2 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 ISO PID PID:200018 NCBI chrNW_004624785:8,690,039...8,747,160 JBrowse link
G Taok1 TAO kinase 1 ISO RGD
PID		 PMID:20626350 PID:200018 RGD:7240533 NCBI chrNW_004624786:1,920,037...2,054,795
Ensembl chrNW_004624786:1,968,991...2,045,948 		JBrowse link
G Taok2 TAO kinase 2 ISO RGD
PID		 PMID:20626350 PID:200018 RGD:7240533 NCBI chrNW_004624782:13,234,422...13,263,495
Ensembl chrNW_004624782:13,256,085...13,262,626
Ensembl chrNW_004624782:13,256,085...13,262,626 		JBrowse link
G Taok3 TAO kinase 3 ISO PID PID:200018 NCBI chrNW_004624747:15,142,378...15,331,197
Ensembl chrNW_004624747:15,241,065...15,331,935 		JBrowse link
G Traf2 TNF receptor associated factor 2 ISO RGD
PID		 PMID:12215209 PID:200018 RGD:2296020 NCBI chrNW_004624760:952,574...973,511
Ensembl chrNW_004624760:952,574...965,661 		JBrowse link
G Traf6 TNF receptor associated factor 6 ISO PID
RGD		 PMID:20626350 PID:200018 RGD:7240533 NCBI chrNW_004624767:10,729,766...10,803,253
Ensembl chrNW_004624767:10,729,413...10,748,455 		JBrowse link
G Txn thioredoxin ISO PID PID:200018 NCBI chrNW_004624758:1,318,108...1,329,011
Ensembl chrNW_004624758:1,318,529...1,329,011 		JBrowse link
the extracellular signal-regulated Raf/Mek/Erk signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Araf A-Raf proto-oncogene, serine/threonine kinase ISO RGD PMID:22177953 RGD:5686410 NCBI chrNW_004624978:99,605...110,645
Ensembl chrNW_004624978:100,505...110,646 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO RGD PMID:16508002 PMID:17310240 PMID:22177953 RGD:1580106 RGD:1626216 RGD:5686410 NCBI chrNW_004624765:20,766,368...20,951,560
Ensembl chrNW_004624765:20,773,885...20,951,736 		JBrowse link
G Dusp6 dual specificity phosphatase 6 ISO RGD PMID:17208316 RGD:2293881 NCBI chrNW_004624750:17,361,725...17,366,907
Ensembl chrNW_004624750:17,362,515...17,367,739 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 ISO RGD PMID:20445128 RGD:4892084 NCBI chrNW_004624740:26,627,560...26,632,483
Ensembl chrNW_004624740:26,627,473...26,632,027 		JBrowse link
G Hras HRas proto-oncogene, GTPase ISO RGD PMID:22177953 RGD:5686410 NCBI chrNW_004624766:21,907,423...21,913,414
Ensembl chrNW_004624766:21,911,241...21,913,653 		JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO RGD PMID:12388314 PMID:22177953 RGD:5686410 RGD:628557 NCBI chrNW_004624752:13,809,741...13,847,020
Ensembl chrNW_004624752:13,809,775...13,844,166 		JBrowse link
G Ksr1 kinase suppressor of ras 1 ISO RGD PMID:17726577 PMID:22177953 RGD:2293880 RGD:5686410 NCBI chrNW_004624786:206,393...347,356
Ensembl chrNW_004624786:206,600...344,428 		JBrowse link
G Ksr2 kinase suppressor of ras 2 ISO RGD PMID:22177953 RGD:5686410 NCBI chrNW_004624747:15,492,312...15,931,358
Ensembl chrNW_004624747:15,493,281...15,916,052 		JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 ISO RGD PMID:9779826 PMID:12835716 PMID:17310240 RGD:1357969 RGD:1626216 RGD:70317 NCBI chrNW_004624781:6,222,365...6,285,398
Ensembl chrNW_004624781:6,222,365...6,285,531 		JBrowse link
G Map2k2 mitogen-activated protein kinase kinase 2 ISO RGD PMID:17310240 RGD:1626216 NCBI chrNW_004624828:5,489,085...5,511,166
Ensembl chrNW_004624828:5,488,814...5,511,445 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 ISO RGD PMID:9305638 PMID:12835716 RGD:1357969 RGD:2293879 NCBI chrNW_004624759:2,360,655...2,429,189
Ensembl chrNW_004624759:2,363,076...2,428,273 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 ISO RGD PMID:12097495 PMID:12835716 PMID:16955078 PMID:17310240 RGD:1357969 RGD:1626216 RGD:628468 RGD:8553011 NCBI chrNW_004624747:1,296,062...1,389,674
Ensembl chrNW_004624747:1,296,221...1,389,757 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 ISO RGD PMID:12097495 PMID:12835716 PMID:16955078 PMID:17310240 PMID:20080775 RGD:1357969 RGD:1626216 RGD:5508172 RGD:628468 RGD:8553011 NCBI chrNW_004624782:13,150,824...13,158,327
Ensembl chrNW_004624782:13,152,039...13,159,113 		JBrowse link
G Mknk1 MAPK interacting serine/threonine kinase 1 ISO RGD PMID:16421520 PMID:16955078 RGD:2315047 RGD:8553011 NCBI chrNW_004624906:2,442,590...2,494,724
Ensembl chrNW_004624906:2,439,418...2,473,967 		JBrowse link
G Mknk2 MAPK interacting serine/threonine kinase 2 ISO RGD PMID:16421520 RGD:2315047 NCBI chrNW_004624828:6,788,069...6,801,370 JBrowse link
G Nras NRAS proto-oncogene, GTPase ISO RGD PMID:22177953 RGD:5686410 NCBI chrNW_004624772:10,358,554...10,369,371 JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 ISO RGD PMID:10490027 PMID:17126425 RGD:2293882 RGD:2302807 NCBI chrNW_004624747:15,340,020...15,346,960
Ensembl chrNW_004624747:15,339,844...15,346,970 		JBrowse link
G Prkcd protein kinase C delta ISO RGD PMID:12790799 RGD:1642529 NCBI chrNW_004624822:4,035,819...4,062,907
Ensembl chrNW_004624822:4,033,130...4,059,555 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta ISO RGD PMID:15096502 RGD:1642630 NCBI chrNW_004624758:22,065,448...22,182,604
Ensembl chrNW_004624758:22,124,836...22,182,605 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO RGD PMID:9779826 PMID:12835716 PMID:16508002 PMID:17310240 PMID:22177953 RGD:1357969 RGD:1580106 RGD:1626216 RGD:5686410 RGD:70317 NCBI chrNW_004624872:204,357...284,487
Ensembl chrNW_004624872:204,357...269,135 		JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 ISO RGD PMID:16421520 RGD:2315047 NCBI chrNW_004624764:10,527,012...10,566,625
Ensembl chrNW_004624764:10,526,948...10,569,910 		JBrowse link
G Rps6ka2 ribosomal protein S6 kinase A2 ISO RGD PMID:16421520 RGD:2315047 NCBI chrNW_004624785:12,450,686...12,839,563
Ensembl chrNW_004624785:12,657,845...12,839,569 		JBrowse link
G Rps6ka3 ribosomal protein S6 kinase A3 ISO RGD PMID:16421520 RGD:2315047 NCBI chrNW_004624829:4,978,181...5,087,493
Ensembl chrNW_004624829:4,983,282...5,087,485 		JBrowse link
G Rps6ka4 ribosomal protein S6 kinase A4 ISO RGD PMID:16421520 RGD:2315047 NCBI chrNW_004624767:21,958,940...21,970,998
Ensembl chrNW_004624767:21,958,868...21,971,108 		JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 ISO RGD PMID:16421520 RGD:2315047 NCBI chrNW_004624734:11,499,372...11,660,564
Ensembl chrNW_004624734:11,499,637...11,659,536 		JBrowse link
G Rps6ka6 ribosomal protein S6 kinase A6 ISO RGD PMID:16421520 RGD:2315047 NCBI chrNW_004624852:4,287,104...4,492,128
Ensembl chrNW_004624852:4,287,855...4,482,373 		JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 ISO RGD PMID:14711826 RGD:1304283 NCBI chrNW_004624857:4,143,269...4,147,877
Ensembl chrNW_004624857:4,143,270...4,147,877 		JBrowse link
G Shc1 SHC adaptor protein 1 ISO RGD PMID:16699171 RGD:1643182 NCBI chrNW_004624885:2,511,039...2,520,883
Ensembl chrNW_004624885:2,511,240...2,521,155 		JBrowse link
G Smad1 SMAD family member 1 ISO RGD PMID:16427075 RGD:1643230 NCBI chrNW_004624853:4,415,816...4,503,317
Ensembl chrNW_004624853:4,444,876...4,502,496 		JBrowse link
G Spp1 secreted phosphoprotein 1 ISO RGD PMID:15757900 RGD:1581337 NCBI chrNW_004624872:4,505,796...4,513,247
Ensembl chrNW_004624872:4,505,522...4,513,742 		JBrowse link
G Tsc2 TSC complex subunit 2 ISO RGD PMID:15150271 RGD:1580097 NCBI chrNW_004624913:166,931...203,008
Ensembl chrNW_004624913:166,931...202,953 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3922
    signaling pathway 1887
      mitogen activated protein kinase signaling pathway 100
        Erk5 MAPK signaling pathway + 6
        altered mitogen activated protein kinase pathway + 6
        stress-regulated MAPK signaling pathway + 69
        the extracellular signal-regulated Raf/Mek/Erk signaling pathway + 31
Path 2
Term Annotations click to browse term
  pathway 3922
    signaling pathway 1887
      kinase mediated signaling pathway 308
        serine/threonine-specific kinase mediated signaling pathway 286
          mitogen activated protein kinase signaling pathway 100
            Erk5 MAPK signaling pathway + 6
            altered mitogen activated protein kinase pathway + 6
            stress-regulated MAPK signaling pathway + 69
            the extracellular signal-regulated Raf/Mek/Erk signaling pathway + 31
paths to the root